Practical aspects of chimeric antigen receptor T-cell administration: From commercial to point-of-care manufacturing

Chimeric antigen receptor T-cells targeting the CD19 antigen have achieved impressive results in patients with relapsed/refractory (R/R) B-cell malignancies, leading to their approval Nightstand in the European Union and other jurisdictions.In Spain, the 100% academic anti-CD19 CART-cell product varnimcabtagene autoleucel (var-cel, ARI-0001 cells)

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Solving Rescheduling Problems in Dynamic Permutation Flow Shop Environments with Multiple Objectives Using the Hybrid Dynamic Non-Dominated Sorting Genetic II Algorithm

In this work, we seek to design a model that contributes to the study and resolution of a multi-objective rescheduling problem in dynamic permutation flow shop contexts.In this type of problem, where the objectives can be valued in heterogeneous units, the difficulty of achieving an optimal solution leads to finding a set of non-dominated efficient

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